Showing results for: [ Wong, Thomas KF ]
AliStat has been written to allow users to evaluate how complete their multiple sequence alignments (MSA) of nucleotides or amino acids are.
In particular, AliStat allows a user to generate four usef... moreul metrics (i.e. the completeness of an MSA (Ca), of a row in an MSA (Cr), of a column in an MSA (Cc), and of homologous sites in a sub-alignment of sequences i and j (Cij)), each of which will tell the user something useful about the distribution of missing data in an MSA.
The information thus obtained can be used to make educated decisions about how the data in the MSA should be analysed phylogenetically.
The output is a set of informative figures, tables, and sub-alignments.
In addition, AliStat produces information that meets the Minimum Reporting Standard (MRS) for MSAs, a concept that we introduce in Wong TFK, Kalyaanamoorthy S, Meusemann K, Yeates DK, Misof B, Jermiin LS. 2017. AliStat: Quality-control metrics for multiple sequence alignments. Nature Methods (in prep).less
CLSD Strategic: Solving Biodiversity Cha - Bioinformatics Software - Published 02 Jun 2017
HAL-HAS is a program package, comprising HAL-BU, HAL-TD, and HAS, that was written to allow users to infer an optimal model of evolution for a given data set, a given tree.
We introduce a family of n... moreon-stationary and non-homogeneous mixture models that approximate the rate Heterogeneity Across Lineages (HAL) and the rate Heterogeneity Across Sites (HAS) without the assumption of an underlying predefined statistical distribution.less
A program to simulate the evolution of DNA under the mixture models of heterogeneity across lineage and heterogeneity across sites.
Hetero was written to facilitate the development and testing of phy... morelogenetic methods.
In particular, Hetero 2 allows the user to generate nucleotide sequences on a phylogenetic tree under complex conditions.
The complexity of the conditions are such that the evolutionary process can differ from site to site in the DNA as well as from edge to edge in the phylogenetic tree, with the evolutionary process being the variable.
The output is a set of alignments of nucleotides.
For further details, see the manual, which is included with the software.less