HAL-HAS version 1.0.9

Collection Title:

HAL-HAS version 1.0.9

Collection Description:

HAL-HAS is a program package, comprising HAL-BU, HAL-TD, and HAS, that was written to allow users to infer an optimal model of evolution for a given data set, a given tree. We introduce a family of non-stationary and non-homogeneous mixture models that approximate the rate Heterogeneity Across Lineages (HAL) and the rate Heterogeneity Across Sites... more (HAS) without the assumption of an underlying predefined statistical distribution. less

Field of Research:

Bioinformatics ;  Bioinformatics Software

DOI:

https://doi.org/10.4225/08/59309cddb5a6b

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Keywords:

HAS-HAS Software ;  HAL-BU ;  HAL-TD ;  HAS ;  Heterogeneity Across Lineages ;  Heterogeneity Across Sites ;  Bioinformatics

Related Links:

:	HAL-HAS code repository on GitHub
:	Vivek Jayaswal, Thomas K.F. Wong, John Robinson, Leon Poladian, Lars S. Jermiin; Mixture Models of Nucleotide Sequence Evolution that Account for Heterogeneity in the Substitution Process Across Sites and Across Lineages. Syst Biol 2014; 63 (5): 726-742. doi: 10.1093/sysbio/syu036

Supporting Files:

CSIRO_Open_Source_Software_License_Agreement_HAL-HAS.pdf

Lineage:

HAL-HAS was developed as a result of a collaboration involving Lars S Jermiin and Thomas KF Wong (CSIRO Ecosystem Sciences) and Vivek Jayaswal, Leon Poladian, and John Robinson (School of Mathematics and Statistics at the University of Sydney). More specifically, for a given tree and data set: HAL-BU considers heterogeneity in the substitution process across lineages. It starts with the simplest model of evolution (i.e., one that has the same rate matrix on every edge in the tree). It then generates and compares increasingly complex models (i.e., different rate matrices on different edges in the tree) with the aim to identify the optimal model of evolution (i.e., one that neither over- or underestimates the complexity) HAL-TD considers heterogeneity in the substitution process across lineages. It starts with the most complex model of evolution (i.e., one that has a different rate matrix on each edge in the tree). It then generates and compares simples models with the aim to identify the optimal model of evolution HAS considers heterogeneity in the substitution process across sites. It starts with the result from HAL-BU, or HAL-TD, and a simple model of evolution where sites are divided into invariable sites and one set of variable sites. It then increases the sets of variable sites from 1 to 2, 3, 4, 5, and so forth, each time assessing the fit between the tree, model, and data, with the aim to identify the optimal model. The output is the inferred optimal model of evolution of the data for a given tree. For further details, see the manual, which is included with the software.

Credit:

This software was developed by the bioinformatics and phylogenomics team in Ecosystem Sciences, The Commonwealth Scientific and Industrial Research Organisation (CSIRO), Canberra, Australia.

Licence:

GPLv3 Licence with CSIRO Disclaimer

Organisations:

CSIRO (Australia)

Attribution Statement:

Jayaswal, Vivek; Wong, Thomas KF; Robinson, John; Poladian, Leon; Jermiin, Lars (2014): HAL-HAS version 1.0.9. v1. CSIRO. Software Collection. https://doi.org/10.4225/08/59309cddb5a6b

Rights Statement:

All Rights (including copyright) CSIRO 2014.

Access:

The metadata and files (if any) are available to the public.